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Chronic prostatitis/chronic pelvic pain syndrome - pharmacological treatment


There is a substantial list of medications used to treat this disorder. Some of them are:

  • Quercetin has shown effective in a randomized, placebo-controlled trial in chronic prostatitis using 500 mg twice a day for 4 weeks Subsequent studies showed that quercetin, a mast cell inhibitor, reduces inflammation and oxidative stress in the prostate.
  • Pollen extract (Cernilton) has also been shown effective in randomized placebo controlled trials.
  • At least one study suggests that multi-modal therapy (aimed at different pathways such as inflammation and neuromuscular dysfunction simultaneously) is better long term than monotherapy.
  • Commonly used therapies that have not been properly evaluated in clinical trials although there is supportive anecdotal evidence are dietary modification, gabapentin, benzodiazepines and amitriptyline.
  • Therapies shown to be ineffective by randomized placebo/sham controlled trials:

    • Levaquin - antibiotics are generally not recommended. Any improvement on antibiotics is likely to be evanescent, and due to the anti-inflammatory effects of the antibiotic.
    • Alpha blockers for 6 weeks or less. The effectiveness of alpha blockers (tamsulosin, alfuzosin) is questionable in men with CPPS. A 2006 meta analysis found that they are moderately beneficial when the duration of therapy was at least 3 months. However a 2004 trial found no benefit from alfuzosin during 6 weeks of treatment and a 2008 clinical trial of alfuzosin found it was no better than placebo for treating CPPS in treatment naive recently diagnosed men.
    • Transurethral needle ablation of the prostate (TUNA)

Other articles from the section: Prostatitis

Chronic bacterial prostatitis - prognosis

  Over time, the relapse rate is high, exceeding 50%. A 2007 study showed that repeated courses of combination antibiotics may eradicate infection in 83.9% of patients with clinical remission extending throughout a follow-up period of 30 months for 94% of these patients.    

Section: Prostatitis

Chronic prostatitis/chronic pelvic pain syndrome - treatment

  No treatment required. It is standard practice for men with infertility and category IV prostatitis to be given a trial of antibiotics and/or anti-inflammatories however evidence for efficacy are weak. Since signs of asymptomatic prostatic inflammation may sometimes be associated with prostate ...

Section: Prostatitis

Acute prostatitis - signs and symptoms

  Men with this disease often have chills, fever, pain in the lower back and genital area, urinary frequency and urgency often at night, burning or painful urination, body aches, and a demonstrable infection of the urinary tract, as evidenced by white blood cells and bacteria in the urine. Acute prostatitis ...

Section: Prostatitis

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