Sections

Alphabetical list:

A B C D E F G H I J K L M N O P R S T U V W X Y Q Z 1 2 3 4 5 6 7 8 9

News: December 4, 2009

Antidepressants May Change Your Personality

December 4, 2009

Taking antidepressants may not only help alleviate depression, but could make you more extraverted and less neurotic, new research suggests.
Extraversion, which is associated with positive emotions, is believed to help protect from depression, while neuroticism, the tendency to experience negative emotions and emotional instability, is thought to contribute to depression.
Becoming more extraverted and less neurotic may help prevent a relapse of depression, said lead study author Tony Tang, an adjunct professor of psychology at Northwestern University in Evanston, Ill.
"People's personalities actually do change and quite substantially when they go through these antidepressant treatments," Tang said. "In the past, we tended to dismiss the personality changes as a side effect or something not very important. But our study suggests it's actually very important to treatment outcomes."
Extraversion and neuroticism are associated with the serotonin system, the brain's reward center that helps regulate mood, sleep and appetite. In this study, participants took paroxetine, which is sold under the brand name Paxil, a selective serotonin reuptake inhibitor. Other SSRIs include Prozac, Zoloft and Celexa. Though those drugs were not tested, Tang said the impact on the personality would likely be similar.
The study findings are published in the December issue of Archives of General Psychiatry.
The researchers divided 240 adults with a major depressive disorder into three groups: 120 received paroxetine, 60 underwent cognitive therapy and 60 took a placebo. Personalities and depressive symptoms were assessed before, during and after treatment.
All groups experienced some improvement in their depression. But participants taking paroxetine became less neurotic and more extraverted than those receiving cognitive therapy or placebo.
It wasn't that the depressed patients suddenly became happy-go-lucky, carefree social butterflies, Tang said. On scales of extraversion and neuroticism, their levels were still barely in the normal range - but they were better than they were before.
Relapsing after stopping treatment, or even while still receiving treatment, is a problem for people with depression. About two-thirds of patients relapse within a year of halting medications, while about 45 percent to 50 percent relapse even if they're still on medication, Tang said.
"Our findings seem to suggest one of the very good predictors for how well you'll do over the long term is how much your personality changes in response to the medication," he said. "For example, how much your neuroticism improved predicted how likely you were to relapse in a year after the treatment."
Bernard Carroll, scientific director of the Pacific Behavioral Research Foundation in Carmel, Calif., said any excitement over the results should be tempered by the fact that the improvements in depression from taking paroxetine weren't much better than from a placebo or cognitive therapy.
"The study confirms that paroxetine is not an especially effective antidepressant drug," said Carroll, past chairman of the U.S. Food and Drug Administration's (FDA) advisory committee for psychiatric drugs. "In this sample, it barely beat the placebo."
Instead, paroxetine is more commonly prescribed for anxiety disorders, which is why researchers may have noted the personality changes. "Paroxetine wouldn't be anybody's number one choice for depression," Carroll said. "But it just might make sense that improving certain personality dimensions helps the patient's resilience against future relapse."
Deciding whether to take an SSRI or not has to be weighed against possible side effects, Carroll said, citing a recent study in the British Journal of Psychiatry that found that many people taking SSRIs reported feeling that the medications had blunted their emotions, both negative and positive ones. Other side effects may include headache, changes in sleep patterns, gastrointestinal upset and changes in sexual functioning, according to background information in that study.
"This business about the drugs affecting personality is not all necessarily good," Carroll said.
In another study from the December issue of Archives of General Psychiatry, patients with bipolar disorder who were taking antiepileptic drugs did not have an increased risk of suicide.
Anti-seizure drugs - including gabapentin, pregabalin, topiramate and carbamazepine - are not only used to treat epilepsy, but nerve disorder and bipolar disorder, according to background information in study.
Last year, the FDA warned of increased risk of suicidal thoughts and behavior related to the use of anti-seizure drugs but voted not to require a black box warning label about suicide risk.
Researchers from the University of Illinois at Chicago analyzed data on 47,918 patients with bipolar disorder, of which 13,385 patients received one of 11 anti-seizure drugs, while others received lithium or no treatment.
The rates of suicide among those taking anti-seizure drugs were no higher than for those taking lithium or those who received no treatment. And for patients taking anti-seizure drugs, suicide rates were five times higher before starting treatment than afterward.
The researchers said those with more severe illness may be more likely to be prescribed anti-seizure drugs or lithium.


Archive issues: (50)

Archive list: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 [16] 17

October 17, 2011 | Sen. Grassley Seeks FDA Scrutiny of Paxil and Suicide Risk

   WASHINGTON, June 12, 2008 Senator Chuck Grassley has asked the Food and Drug Administration to carefully scrutinize information it received from drug maker GlaxoSmithKline about the anxiety disorder drug Paxil, based on the contents of a newly available report about the drug's risk for suicide among ...

September 21, 2009 | Topical cream studied for erectile dysfunction

Scientists from Albert Einstein College of Medicine of Yeshiva University are working on a cream to rub on and treat erectile dysfunction (ED). The cream could prove to be safer than oral medications used to deliver nitric oxide to the cells that improves blood flow to treat impotency. Using encapsulated nanoparticles, the scientists have found a way to deliver nitric oxide and prescription drugs that penetrate ...

May 21, 2012 | Onyx Rises on Analyst View of Blood Cancer Drug

NEW YORK -- Onyx Pharmaceuticals Inc. shares rose Thursday after a Bernstein Research analyst started covering the stock with an "Outperform" rating, saying he thinks the companyís blood cancer drug candidate will reach $1 billion in annual sales by 2016.   THE SPARK: Analyst Geoffrey Porges said he thinks that the drug, Kyprolis, will ...

Archive list: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 [16] 17

Related articles:

Clinical Tests Used to Diagnose ED

  Duplex ultrasound (Duplex ultrasound is used to evaluate blood flow, venous leak, signs of atherosclerosis, and scarring or calcification of erectile tissue. Injecting prostaglandin, a hormone-like stimulator produced in the body, induces erection. Ultrasound is then used to see vascular dilation and ...

Section: Erectile Dysfunction

Oral treatment

  The cyclic nucleotide phosphodiesterases constitute a group of enzymes that catalyse the hydrolysis of the cyclic nucleotides cyclic AMP and cyclic GMP. They exist in different molecular forms and are unevenly distributed throughout the body.  One of the forms of phophodiesterase is termed PDE5. The prescription PDE5 inhibitors sildenafil (Viagra), vardenafil (Levitra) and tadalafil (Cialis) are prescription drugs which are taken orally. They work by blocking the action of PDE5, which causes cGMP to degrade. CGMP ...

Section: Erectile Dysfunction

Treatment - pain control

  Pain control is usually necessary in the IC/PBS treatment plan. The pain of IC/PBS has been rated equivalent to cancer pain and may lead to central sensitization if untreated.  Medication. The use of a variety of traditional pain medications, including opiates and synthetic opioids like tramadol, is often necessary to treat the varying degrees of pain. Even children with IC/PBS should be appropriately addressed regarding pelvic pain, and receive necessary treatment to manage ...

Section: Interstitial cystitis

News

December 20, 2009

Wii, Xbox 360 and Other Video Games Offer Some Benefits

Wii, Xbox 360, PlayStation, and other video games are hot on holiday gift lists, but some parents wonder whether these games offer any benefits or are detrimental to kids. The results of a new study may put ...

December 18, 2009

Should You Be Shoveling Snow?

Yes, the weather outside is frightful, and soon you will have to think about shoveling snow. But should you be the one doing the work? Who should and should not shovel snow, and how can you do it safely?  Every winter, approximately 1,200 Americans die from a heart attack or ...

December 17, 2009

Athletes who take NSAID's to prevent pain may be doing more harm than good

According to Stuart Warden, a researcher who studies musculoskeletal health and sports medicine, athletes who ritualistically take NSAID's to prevent post event and workout soreness and ...

Blogroll