Sections

Alphabetical list:

A B C D E F G H I J K L M N O P R S T U V W X Y Q Z 1 2 3 4 5 6 7 8 9

News: November 29, 2009

Rituximab May Offer Hope To Severe Graves' Eye Disease Patients

November 29, 2009

There may be hope for patients with severe Graves' eye disease in the form of treatment with the drug rituximab.

This news comes from U-M Kellogg Eye Center who's oculoplastics specialist Raymond S. Douglas, M.D., Ph.D. reports on the potential of the drug in the online October issue of Ophthalmology.

Graves' eye disease is an autoimmune disease that causes inflammation and fatty deposits in the eye muscles and connective tissue surrounding the eye.

Douglas reports on the progress of six patients (four women, two men) who had not responded to treatment using systemic corticosteroids. The patients were then treated with rituximab. All patients responded within 2 months with the clinical activity score (CAS) improving from5.50.8 to 1.30.5. The eye disease remained quiescent in all with the positive results being sustained at 4-6 months after treatment.

Vision improved bilaterally in all 4 patients with dysthyroid optic neuropathy (DON). Proptosis remained stable (Hertel measurement, 243.7 mm before therapy and 23.63.7 mm after therapy; P = 0.17).

"These patients had already received the maximum level of steroid treatment," says Douglas. "Treatment with rituximab calmed inflammation, stopped progression of the disease, and saved the patients from having to undergo surgery."

Graves' disease (also known as thyroid eye disease) is an autoimmune condition in which white blood cells attack the thyroid gland which responds by secreting an excess amount of thyroid hormone. The hypermetabolic state is characterized by fast pulse/heartbeat, palpitations, profuse sweating, high blood pressure, irritability, fatigue, weight loss, heat intolerance, and loss of hair and alterations in hair quality.

Rituximab has been used to treat patients with other autoimmune diseases, including rheumatoid arthritis and in non-Hodgkin's B-cell lymphoma. The drug works by depleting B cells - the body's normal antibody-producing cells - that appear to go awry in autoimmune diseases.

"Treatment of the inflammatory component of Graves' eye disease has not advanced appreciably over several decades," says Douglas. High-dose steroids, sometimes in combination with orbital radiation, are still the first line treatment. But, says Douglas, "These are imperfect options because inflammation often recurs when the treatment ends." He is hopeful that rituximab can offer sustained improvement. Douglas observes that the results from a small case series must be viewed with some caution. But given the substantial benefits for patients treated with rituximab, he sees good reason to proceed with a large-scale clinical trial to test this promising new drug.

Source

Rituximab Treatment of Patients with Severe, Corticosteroid-Resistant Thyroid-Associated Ophthalmopathy; Ophthalmology, 2009; Chong et al.; DOI: 10.1016/j.ophtha.2009.05.029


University of Michigan Health System Newsroom



Archive issues: (50)

Archive list: 1 2 3 4 [5] 6 7 8 9 10 11 12 13 14 15 16 17

December 2, 2009 | Fatty acids in diet affect ulcerative colitis risk

People who eat lots of red meat, cook with certain types of oil, and use some kinds of polyunsaturated fatty acid (PUFA)-heavy margarines may be increasing their risk of a painful inflammatory bowel disease, a study in more than 200,000 Europeans shows.  These foods are high in linoleic acid and the study have found that people who were the heaviest consumers of this omega-6 PUFA were more than twice as likely to develop ulcerative ...

December 1, 2009 | Ecstasy Users at Higher Risk of Sleep Apnea

The widely used club drug ecstasy appears to increase the risk of sleep apnea, say U.S. researchers.  "People who use ecstasy need to know that this drug damages the brain and can cause immediate and dangerous problems such as sleep apnea," study author Dr. Una McCann, of the Johns Hopkins School of Medicine in Baltimore, ...

November 30, 2009 | Switching to Light Cigarettes Will Not help you Quit Smoking

The Center of Disease Control (CDC) says that there are 44 million American smokers and many of these smokers are looking for ways to quit. Some smokers in an attempt to kick the habit are switching to "light" or "ultra light" to help their battle against nicotine, however, a new study suggests switching to a lighter cigarerette does not help.  A newly published study published in the November 2009 issue ...

Archive list: 1 2 3 4 [5] 6 7 8 9 10 11 12 13 14 15 16 17

Related articles:

Treatment - surgery

  Surgical interventions are rarely used for IC/PBS. Surgical intervention is very unpredicatable for IC/PBS, and is considered a treatment of last resort when all other treatment modalities have failed and pain is severe. Some patients who opt for surgical intervention continue to experience pain after surgery. Surgical interventions ...

Section: Interstitial cystitis

Independence and invulnerability - masculine gender role stress

  Some men feel stressed by societal pressure to act masculine. These men feel that they have to prevail in situations that require physical strength and fitness. To appear weak, emotional, or sexually inefficient is a major threat to their self-esteem. To be content, these men must ...

Section: Mens health risks

About mens health risks

  Mortality rates for all of the 15 leading causes of death for the total population are higher for males than females in America. Men die almost seven years earlier than women. Men are more likely to suffer from chronic illnesses, to suffer a traumatic brain injury, and to die from acquired immune deficiency syndrome (AIDS). Men are less likely to exercise and are more likely to be overweight. They are also less likely to take nutritional supplements, ...

Section: Mens health risks

News

December 20, 2009

Wii, Xbox 360 and Other Video Games Offer Some Benefits

Wii, Xbox 360, PlayStation, and other video games are hot on holiday gift lists, but some parents wonder whether these games offer any benefits or are detrimental to kids. The results of a new study may put some minds at ease, while others may not.  According to the findings reported in ...

December 18, 2009

Should You Be Shoveling Snow?

Yes, the weather outside is frightful, and soon you will have to think about shoveling snow. But should you be the one doing the work? Who should and should not shovel snow, and how can you do it safely?  Every winter, approximately 1,200 Americans die from a heart attack or ...

December 17, 2009

Athletes who take NSAID's to prevent pain may be doing more harm than good

According to Stuart Warden, a researcher who studies musculoskeletal health and sports medicine, athletes who ritualistically take NSAID's to prevent post event and workout soreness and inflammation may be depriving the body of healing, in addition to risking other ...

Blogroll