Sections

Alphabetical list:

A B C D E F G H I J K L M N O P R S T U V W X Y Q Z 1 2 3 4 5 6 7 8 9

News: November 23, 2009

Genetic Variant Slows AIDS Progression

November 23, 2009

Scientists report that a genetic variation appears to play a major role in slowing disease progression in HIV-infected patients.
In fact, those with the variation appear to take years longer to develop AIDS and die of complications of the disease.
"We're honing in on factors that vary across individuals that make a person more or less susceptible to HIV, in terms of how rapidly someone develops the disease," said study co-author Mary Carrington, a senior principal investigator at the U.S. National Cancer Institute.
However, this new knowledge won't translate into immediate benefits for patients with HIV.
AIDS remains a major killer in many parts of the world, but HIV - the virus that causes it - doesn't affect infected people the same way. "People progress to AIDS at hugely different rates," Carrington explained. "Some people progress within a year, while some have been infected for 20 years and still control the virus and don't have the disease."
It appears that three factors affect how the disease strikes a person, she said. One is the environment: the world in which a person lives. Another is the patient's genetic makeup. And the third is the genetic makeup of the virus itself.
In the study, published in the Nov. 22 online edition of Nature Genetics, Carrington and colleagues looked at genetic and medical records for hundreds of HIV-infected men. They were trying to see if genetic variations affected how the men fared.
The researchers found that a variation linked to higher levels of a protein known as HLA-C boosted the men's ability to avoid progressing to AIDS. It appeared to delay both the progression to AIDS and to death by years, Carrington said.
The genetic variation makes it easier for the immune system to kill cells that have been infected with the virus, she said. It does this by allowing immune cells to gain greater access to the infected cells, she explained.
Carrington said this genetic variation isn't related to another gene-related trait that makes some people virtually immune to HIV.
The study "hints at ways we might ultimately develop a vaccine or immune-based therapies that could modify or maybe even prevent the development of HIV disease," said Rowena Johnston, vice president of research with the Foundation for AIDS Research in New York City.
"The finding that a single piece of DNA can be strongly associated with something as complex as the control of HIV soon after infection is especially intriguing, not least because we know that early control of infection sets the stage for the entire course of the disease," Johnston noted.
What's next? The ultimate goal, Carrington said, is "to have a complete list of every genetic variance that is affecting how rapidly the disease develops."
That, in turn, could help physicians figure out how to better treat patients.


Archive issues: (50)

Archive list: 1 2 3 4 5 6 7 8 9 10 11 [12] 13 14 15 16 17

November 11, 2009 | Treatment for Sleep Apnea Can Improve Golf Game

Men with obstructive sleep apnea (OSA) who received nasal continuous positive airway pressure (NCPAP or NPAP) treatments not only improved their health, but also lowered their golf handicap by as much as three strokes, according to research presented at CHEST ...

November 10, 2009 | More Insurance Companies Are Paying For Alternative Medicine

Alternative medicine which was once thought to be controversial and experimental is now gaining newfound respect within the medical community. In fact so much respect that more insurance companies are beginning to pay for alternative ...

November 9, 2009 | Two Antibiotics Linked to Birth Defects

Most antibiotics used during pregnancy are safe, but researchers have found a link between two commonly prescribed drugs and birth defects.  The study, part of the National Birth Defects Prevention Study and published in the November issue of Archives of Pediatrics and Adolescent Medicine, is the first analysis of antibiotic ...

Archive list: 1 2 3 4 5 6 7 8 9 10 11 [12] 13 14 15 16 17

Related articles:

Treatment - medication (pentosan polysulfate)

  Oral pentosan polysulfate (Elmiron) is believed to provide a protective coating in the bladder, but studies show it is not statistically significant compared to placebo. However, some studies have found that a minority of patients do respond to pentosan polysulfate.    

Section: Interstitial cystitis

Chronic prostatitis/chronic pelvic pain syndrome - diagnosis

  Diagnosis is through tests of semen, expressed prostatic secretion (EPS) or prostate tissue that reveal inflammation in the absence of symptoms.    

Section: Prostatitis

Risk-taking - alcohol consumption behavior

  Research on beer commercials by Strate (Postman, Nystrom, Strate, And Weingartner 1987; Strate 1989, 1990) and by Wenner (1991) show some interesting results. In beer commercials, the ideas of masculinity (especially risk-taking) are presented and encouraged. The commercial focuses on a situation where a man is overcoming an obstacle in a group. ...

Section: Mens health risks

News

December 20, 2009

Wii, Xbox 360 and Other Video Games Offer Some Benefits

Wii, Xbox 360, PlayStation, and other video games are hot on holiday gift lists, but some parents wonder whether these games offer any benefits or are detrimental to kids. The results of a new study may put some minds at ease, while others may ...

December 18, 2009

Should You Be Shoveling Snow?

Yes, the weather outside is frightful, and soon you will have to think about shoveling snow. But should you be the one doing the work? Who should and should not shovel snow, and how can you do it safely?  Every ...

December 17, 2009

Athletes who take NSAID's to prevent pain may be doing more harm than good

According to Stuart Warden, a researcher who studies musculoskeletal health and sports medicine, athletes who ritualistically take NSAID's to prevent post event and workout soreness and inflammation may be depriving the ...

Blogroll