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News: November 9, 2009

Two Antibiotics Linked to Birth Defects

November 9, 2009

Most antibiotics used during pregnancy are safe, but researchers have found a link between two commonly prescribed drugs and birth defects.

The study, part of the National Birth Defects Prevention Study and published in the November issue of Archives of Pediatrics and Adolescent Medicine, is the first analysis of antibiotic use in pregnancy. Researchers analyzed data from 13,155 mothers in 10 states whose infants had birth defects and compared them to mothers in the same region who had healthy babies.

It found that mothers of babies with birth defects were more likely to report taking two types of antibiotics used to treat urinary tract infections during the first three months of pregnancy - sulfa drugs such as Bactrim and Septra, and nitrofurantoins, a urinary germicide that includes the brand names Furadantin, Macrobid, and Macrodantin.

Penicillin, the most commonly prescribed antibiotic in early pregnancy, was found to be safe, but was linked to a slightly increased risk for limb defects. Also found to be safe were cephalosporins and quinolones.

Lead author of the study, Krista Crider, a geneticist with the Centers for Disease Control and Prevention said that this was the first study to find an association with the drugs and birth defects and additional studies are need to confirm the findings.

Sulfa drugs are the oldest antibiotics and some animal studies have found harm during pregnancy. The study found this group of drugs to be associated with six birth defects, more than any other class of antibiotic. Defects linked to sulfa drugs included rare brain and heart defects and shortened limbs. Anencephaly, a fatal brain and skull malformation linked to sulfa drugs, affects about 1 in 10,000 births in the United States per March of Dimes data.

Doctors have previously viewed nitrofurantoins as safe to treat urinary tract infections during pregnancy. The four defects most commonly linked with these medications included hypoplastic left heart syndrome, atrial septal defect, eye defects, and cleft lip and palate. Cleft palate occurs in about 20 births out of 10,000 and was twice as likely to occur with women who had taken the nitrofurantoins.

It is unclear whether the birth defects were caused by the drugs or by the infections being treated. Bacterial infections themselves can cause problems for the fetus if left untreated, including preterm birth, low birth weight and blindness, so pregnant women shouldn't avoid antibiotics entirely. Instead, women should discuss antibiotics choices with their doctors.

Additional Sources Include: The Centers for Disease Control and Prevention and the March of Dimes



Archive issues: (50)

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December 08, 2009 | Tamiflu May Be Inneffective In Fighting Effects Of Flu

Washington (SmartAboutHealth) - According to a new review, the popular Tamiflu is weak when it comes to the effect it has in preventing effects of the flu, such as the development of pneumonia.  The new review was carried out by researchers in Great Britain, and puts into question the highly-popular flu drug.  Tamiflu was the focus of this update to a review that was published back in 2006, and it looked into a total of 20 published clinical trials on the ...

December 7, 2009 | Surprised? Black market steroids usually mislabeled

The risks of anabolic steroids - used by some athletes to build muscle mass - are by now well-documented. But it turns out, perhaps not surprisingly, that steroids bought illegally through "underground labs" and over the internet generally aren't what their labels say they are, researchers reported yesterday at the American Academy of Addiction Psychiatry's annual meeting in Los Angeles.  Steroid users ...

December 6, 2009 | Prostate Hormone Therapy May Up Heart Risks

Diabetes, heart attacks and other cardiovascular problems appear to be more common in men with prostate cancer who are treated with androgen deprivation therapy, which reduces or eliminates the male sex hormones that can ...

Archive list: 1 2 [3] 4 5 6 7 8 9 10 11 12 13 14 15 16 17

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