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News: November 9, 2009

Two Antibiotics Linked to Birth Defects

November 9, 2009

Most antibiotics used during pregnancy are safe, but researchers have found a link between two commonly prescribed drugs and birth defects.

The study, part of the National Birth Defects Prevention Study and published in the November issue of Archives of Pediatrics and Adolescent Medicine, is the first analysis of antibiotic use in pregnancy. Researchers analyzed data from 13,155 mothers in 10 states whose infants had birth defects and compared them to mothers in the same region who had healthy babies.

It found that mothers of babies with birth defects were more likely to report taking two types of antibiotics used to treat urinary tract infections during the first three months of pregnancy - sulfa drugs such as Bactrim and Septra, and nitrofurantoins, a urinary germicide that includes the brand names Furadantin, Macrobid, and Macrodantin.

Penicillin, the most commonly prescribed antibiotic in early pregnancy, was found to be safe, but was linked to a slightly increased risk for limb defects. Also found to be safe were cephalosporins and quinolones.

Lead author of the study, Krista Crider, a geneticist with the Centers for Disease Control and Prevention said that this was the first study to find an association with the drugs and birth defects and additional studies are need to confirm the findings.

Sulfa drugs are the oldest antibiotics and some animal studies have found harm during pregnancy. The study found this group of drugs to be associated with six birth defects, more than any other class of antibiotic. Defects linked to sulfa drugs included rare brain and heart defects and shortened limbs. Anencephaly, a fatal brain and skull malformation linked to sulfa drugs, affects about 1 in 10,000 births in the United States per March of Dimes data.

Doctors have previously viewed nitrofurantoins as safe to treat urinary tract infections during pregnancy. The four defects most commonly linked with these medications included hypoplastic left heart syndrome, atrial septal defect, eye defects, and cleft lip and palate. Cleft palate occurs in about 20 births out of 10,000 and was twice as likely to occur with women who had taken the nitrofurantoins.

It is unclear whether the birth defects were caused by the drugs or by the infections being treated. Bacterial infections themselves can cause problems for the fetus if left untreated, including preterm birth, low birth weight and blindness, so pregnant women shouldn't avoid antibiotics entirely. Instead, women should discuss antibiotics choices with their doctors.

Additional Sources Include: The Centers for Disease Control and Prevention and the March of Dimes



Archive issues: (50)

Archive list: 1 2 3 4 5 6 7 8 9 [10] 11 12 13 14 15 16 17

November 17, 2009 | Consumer Reports Finds BPA in Common Canned Foods

In the upcoming December 2009 magazine, Consumer Reports details the testing they have done on dozens of canned food products such as soups, juice, tuna fish and vegetables, for the chemical Bisphenol A, or BPA. The products tested included 19 of the most common brand names such as Campbell's, Chef Boyardee, Del Monte, Nestle, and Progresso.  BPA is a plastic hardener and a component of epoxy resin. It is used in many products, including plastic ...

November 16, 2009 | Steroid Concern Prompts Bodybuilding Supplement Recall

In a press release issued November 3, 2009, Bodybuilding.com LLC, an online supplement retailer, announced that it was conducting a voluntary recall of 65 dietary supplements that were sold through the company's website. The recall is for all lots and expiration dates sold both nationwide and ...

November 15, 2009 | Breastfeeding Benefits Updated by the American Dietetic Association

The health benefits of breastfeeding for both infants and their mothers have been updated and explained in a newly released position paper by the American Dietetic Association (ADA). The ADA strongly encourages breastfeeding whenever possible, noting that it is the "optimal feeding method for the infant."  When one looks at the statistics on breastfeeding in the United ...

Archive list: 1 2 3 4 5 6 7 8 9 [10] 11 12 13 14 15 16 17

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