Sections

Alphabetical list:

A B C D E F G H I J K L M N O P R S T U V W X Y Q Z 1 2 3 4 5 6 7 8 9

News: November 5, 2009

To Quit Smoking, Use Patch Plus Lozenge

November 5, 2009

Out of five different smoking cessation methods, the nicotine patch plus lozenges proved to be the most effective, according to research published in the November issue of Archives of General Psychiatry. The study is the first to compare the different products against each other.

Megan E. Piper, PhD and colleagues at the University of Wisconsin School of Medicine and Public Health found this combination to be the only modality with significantly higher abstinence from smoking compared with a placebo.

The researchers studied over 1500 adults over a period of six months who smoked at least 10 cigarettes a day. The patients were disqualified if they used any form of tobacco other than cigarettes, were currently taking the prescription medication buproprion, or had a mental health diagnosis of either psychosis or schizophrenia. All participants stated a motivation to quit smoking.

Bupropion is the generic name of the medication used as a smoking cessation drug (brand name Zyban) and as an antidepressant (Wellbutrin).

The participants were randomized to one of five treatment scenarios - nicotine lozenge alone, nicotine patch alone, sustained release buproprion alone or one of two combination therapies, buproprion plus lozenge or patch plus lozenge. The remainder of the study group received a placebo. All participants also received six individual smoking cessation counseling sessions with a case manager.

Smoking rates were assessed at one week, eight weeks, and six months after the beginning of the study.

All of the smoking cessation treatments worked better than the placebo for initial cessation and during the first week after quitting, but the therapy that provided the highest abstinence rate after six months was the patch plus lozenge combination, with a 40% success rate. The reasoning behind the successful combination is that the patch supplies a steady supply of nicotine replacement while the lozenge quells additional cravings.

In addition to initial cessation, participants who combined the patch and the lozenge were better able to remain smoke-free longer before having a cigarette or relapsing into regular smoking.

There were adverse events noted in each modality that was consistent with results from previous research: skin irritation associated with patch use, sleep disturbances and abnormal dreams for those on bupropion, and nausea for those on lozenges. Patients in the combination therapies reported more of the complications than those on single therapies or placebo. Four participants withdrew from the study, but there was only one serious event, hospitalization for seizures, which was possibly related to study medication, the researchers said.

The findings of this study complement the recommendation of the 2008 Update to the Public Health Service Treating Tobacco Use and Dependence Clinical Practice Guideline, which says that using the nicotine patch along with nicotine gum or spray is the most effective methods to quit smoking.



Archive issues: (50)

Archive list: 1 2 3 4 5 6 7 [8] 9 10 11 12 13 14 15 16 17

November 23, 2009 | Genetic Variant Slows AIDS Progression

Scientists report that a genetic variation appears to play a major role in slowing disease progression in HIV-infected patients.  In fact, those with the variation appear to take years longer to develop AIDS and die of complications of the disease.  "We're honing in on factors that vary across individuals that make a person more or less susceptible to HIV, in terms of how rapidly ...

November 22, 2009 | FDA To Reduce the Misuse of Medications

The FDA wants to reduce the misuse of medications, saying that at least 50,000 hospitalizations a year could be prevented if physicians, pharmacists, patients and parents would be more careful. And the cost of these preventable injuries is estimated at about $4 billion annually by the Institute of Medicine.  FDA commissioner Margaret A. Hamburg stated, "when I first started looking at this, I was stunned at the scope of ...

November 21, 2009 | Diabetes Drug Byetta Linked to Kidney Problems

The FDA has received 78 reports of kidney problems related to Byetta, a drug by Amylin Pharmaceuticals and Eli-Lilly prescribed to treat type 2 diabetes. With the new findings, the drug's label will be updated to warn doctors and ...

Archive list: 1 2 3 4 5 6 7 [8] 9 10 11 12 13 14 15 16 17

Related articles:

Treatment - surgery

  Surgical interventions are rarely used for IC/PBS. Surgical intervention is very unpredicatable for IC/PBS, and is considered a treatment of last resort when all other treatment modalities have failed and pain is severe. Some patients who opt for surgical intervention continue to experience pain after surgery. Surgical ...

Section: Interstitial cystitis

Treatment

  Treatment depends on the cause. Testosterone supplements may be used for cases due to hormonal deficiency. However, the cause is more usually lack of adequate penile blood supply as a result of damage to inner walls of blood vessels. This damage is more frequent in older men, and often associated with disease, in particular ...

Section: Erectile Dysfunction

Treatment - medication (bladder instillations)

  DMSO, a wood pulp extract, is the only approved bladder instillation for IC/PBS yet it is much less frequently used in urology clinics. Research studies presented at recent conferences of the American Urological Association by C. Subah Packer have demonstrated that the FDA approved dosage of a 50% ...

Section: Interstitial cystitis

News

December 20, 2009

Wii, Xbox 360 and Other Video Games Offer Some Benefits

Wii, Xbox 360, PlayStation, and other video games are hot on holiday gift lists, but some parents wonder whether these games offer any benefits or are detrimental to kids. The results of a new study may put some minds at ease, while others may not.  According to the findings reported in the latest issue of Current Directions ...

December 18, 2009

Should You Be Shoveling Snow?

Yes, the weather outside is frightful, and soon you will have to think about shoveling snow. But should you be the one doing the work? Who should and should not shovel snow, and how can you do it safely?  Every winter, ...

December 17, 2009

Athletes who take NSAID's to prevent pain may be doing more harm than good

According to Stuart Warden, a researcher who studies musculoskeletal health and sports medicine, athletes who ritualistically take NSAID's to prevent post event and workout soreness and inflammation may be depriving the body of healing, in addition to risking other long term health problems. Taking anti inflammatory medications before running or other athletic ...

Blogroll