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News: November 5, 2009

To Quit Smoking, Use Patch Plus Lozenge

November 5, 2009

Out of five different smoking cessation methods, the nicotine patch plus lozenges proved to be the most effective, according to research published in the November issue of Archives of General Psychiatry. The study is the first to compare the different products against each other.

Megan E. Piper, PhD and colleagues at the University of Wisconsin School of Medicine and Public Health found this combination to be the only modality with significantly higher abstinence from smoking compared with a placebo.

The researchers studied over 1500 adults over a period of six months who smoked at least 10 cigarettes a day. The patients were disqualified if they used any form of tobacco other than cigarettes, were currently taking the prescription medication buproprion, or had a mental health diagnosis of either psychosis or schizophrenia. All participants stated a motivation to quit smoking.

Bupropion is the generic name of the medication used as a smoking cessation drug (brand name Zyban) and as an antidepressant (Wellbutrin).

The participants were randomized to one of five treatment scenarios - nicotine lozenge alone, nicotine patch alone, sustained release buproprion alone or one of two combination therapies, buproprion plus lozenge or patch plus lozenge. The remainder of the study group received a placebo. All participants also received six individual smoking cessation counseling sessions with a case manager.

Smoking rates were assessed at one week, eight weeks, and six months after the beginning of the study.

All of the smoking cessation treatments worked better than the placebo for initial cessation and during the first week after quitting, but the therapy that provided the highest abstinence rate after six months was the patch plus lozenge combination, with a 40% success rate. The reasoning behind the successful combination is that the patch supplies a steady supply of nicotine replacement while the lozenge quells additional cravings.

In addition to initial cessation, participants who combined the patch and the lozenge were better able to remain smoke-free longer before having a cigarette or relapsing into regular smoking.

There were adverse events noted in each modality that was consistent with results from previous research: skin irritation associated with patch use, sleep disturbances and abnormal dreams for those on bupropion, and nausea for those on lozenges. Patients in the combination therapies reported more of the complications than those on single therapies or placebo. Four participants withdrew from the study, but there was only one serious event, hospitalization for seizures, which was possibly related to study medication, the researchers said.

The findings of this study complement the recommendation of the 2008 Update to the Public Health Service Treating Tobacco Use and Dependence Clinical Practice Guideline, which says that using the nicotine patch along with nicotine gum or spray is the most effective methods to quit smoking.



Archive issues: (50)

Archive list: 1 2 3 4 5 6 7 8 9 [10] 11 12 13 14 15 16 17

November 17, 2009 | Consumer Reports Finds BPA in Common Canned Foods

In the upcoming December 2009 magazine, Consumer Reports details the testing they have done on dozens of canned food products such as soups, juice, tuna fish and vegetables, for the chemical Bisphenol A, or BPA. The products tested included 19 of the most common brand names such as Campbell's, Chef Boyardee, Del Monte, Nestle, and Progresso.  BPA is a plastic ...

November 16, 2009 | Steroid Concern Prompts Bodybuilding Supplement Recall

In a press release issued November 3, 2009, Bodybuilding.com LLC, an online supplement retailer, announced that it was conducting a voluntary recall of 65 dietary supplements that were sold through the company's website. The recall is for all lots and expiration dates sold both nationwide and internationally.  The FDA states they have conducted a two-year investigation in which products bought from bodybuilding.com were ...

November 15, 2009 | Breastfeeding Benefits Updated by the American Dietetic Association

The health benefits of breastfeeding for both infants and their mothers have been updated and explained in a newly released position paper by the American Dietetic Association (ADA). The ADA strongly encourages breastfeeding whenever possible, noting that it is the "optimal feeding method for the infant."  When one looks at the statistics on breastfeeding in the United States, the figures are disappointing. The Centers for Disease Control and Prevention statistics ...

Archive list: 1 2 3 4 5 6 7 8 9 [10] 11 12 13 14 15 16 17

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